[Global environmental changes and the epithelial barrier hypothesis]. / Globale Umweltveränderungen und die "epithelial barrier hypothesis".

BACKGROUND: The global burden of noncommunicable diseases (NCD) has seen a strong increase in recent decades and attributable to the influence of environmental factors. For a multitude of diseases an association with epithelial barrier damage has been reported. OBJECTIVE: This article provides an overview of the health effects of environmental pollution in the context of the epithelial barrier hypothesis of Cezmi Akdis. Additionally, exemplary mechanisms of a barrier damage are described. Finally, possible preventive and therapeutic consequences are discussed. MATERIAL AND METHODS: The PubMed database was searched for the relevant topics and selected literature was reviewed. RESULTS: A wide variety of substances can damage the epithelial barriers of the skin, lungs and gastrointestinal tract. The rise in the prevalences of atopic diseases could (partly) be due to an increased exposure to barrier-damaging substances, such as particulate matter and laundry detergents. A possible pathogenetic mechanism is the initiation and maintenance of an immune response by subepithelial penetration of microorganisms through damaged epithelia. CONCLUSION: Based on the epithelial barrier hypothesis new therapeutic and prevention strategies can be developed. The regulation of hazardous chemicals and the fight against environmental pollution and climate change are necessary to reduce the burden of disease.

Time is of the essence: The importance of considering biological rhythms in an increasingly polluted world.

Biological rhythms have a crucial role in shaping the biology and ecology of organisms. Light pollution is known to disrupt these rhythms, and evidence is emerging that chemical pollutants can cause similar disruption. Conversely, biological rhythms can influence the effects and toxicity of chemicals. Thus, by drawing insights from the extensive study of biological rhythms in biomedical and light pollution research, we can greatly improve our understanding of chemical pollution. This Essay advocates for the integration of biological rhythmicity into chemical pollution research to gain a more comprehensive understanding of how chemical pollutants affect wildlife and ecosystems. Despite historical barriers, recent experimental and technological advancements now facilitate the integration of biological rhythms into ecotoxicology, offering unprecedented, high-resolution data across spatiotemporal scales. Recognizing the importance of biological rhythms will be essential for understanding, predicting, and mitigating the complex ecological repercussions of chemical pollution.

The Impact of Economic Corridor and Tourism on Local Community's Quality of Life under One Belt One Road Context.

Economic corridors unlock new economic opportunities and tourism development in the region to achieve sustainable development goals. Green economic growth is conducive to environmental sustainability. Economic mega-projects of CPEC promote tourism that leads to communities' well-being and better quality of life. Modern infrastructure development contributes significantly to economic growth and tourism activities. This study's objectives emphasize exploring tourism and sustainable development pursuits under OBOR economic projects that open doors to improving residents' quality of life. The growing world is an eyewitness to a continuous rise in emissions and its severe consequences for humankind. It is necessary to show off the leading factors that result in tourism and economic activities causing environmental pollution rather than blame policymakers. Undoubtedly, many studies previously focused on demonstrating the influence of socio-economic factors that lead to better environmental quality. However, the empirical literature on tourism, social well-being, foreign direct investment, and the Environment in Belt and Road developed economies needed improvement. This research applied a series of advanced estimators that help demonstrate the study's probable results. This study explores the role of Social well-being (HDI), tourism development, FDI, renewable energy, information & communication technology (ICT), and urbanization on CO2 emissions in Belt and Road (BRI) developed economies.Estimated results exhibited the significant contribution of ICT and renewable energy to sustainability. Besides, FDI contributes to emissions reduction after its threshold level. Conversely, urbanization and tourism activities contribute to environmental pollution. The study outcomes stated inverted/EKC U-shaped hypotheses related to specified economies. Finally, the analysis based on the D-H panel causality test constructs exciting results.The present study concludes that economic corridor plays a vital role in tourism development, the community's well-being, and SDGs goals (sustainable development) impact on environmental safety. The findings suggest essential and applicable policies to attain the desired sustainability level. Findings contribute to the literature on tourism, well-being, and sustainability. Further studies can use insights using this methodology.

Soils in distress: The impacts and ecological risks of (micro)plastic pollution in the terrestrial environment.

Plastics have revolutionised human industries, thanks to their versatility and durability. However, their extensive use, coupled with inadequate waste disposal, has resulted in plastic becoming ubiquitous in every environmental compartment, posing potential risks to the economy, human health and the environment. Additionally, under natural conditions, plastic waste breaks down into microplastics (MPs<5 mm). The increasing quantity of MPs exerts a significant burden on the soil environment, particularly in agroecosystems, presenting a new stressor for soil-dwelling organisms. In this review, we delve into the effects of MP pollution on soil ecosystems, with a specific attention to (a) MP transport to soils, (b) potential changes of MPs under environmental conditions, (c) and their interaction with the physical, chemical and biological components of the soil. We aim to shed light on the alterations in the distribution, activity, physiology and growth of soil flora, fauna and microorganisms in response to MPs, offering an ecotoxicological perspective for environmental risk assessment of plastics. The effects of MPs are strongly influenced by their intrinsic traits, including polymer type, shape, size and abundance. By exploring the multifaceted interactions between MPs and the soil environment, we provide critical insights into the consequences of plastic contamination. Despite the growing body of research, there remain substantial knowledge gaps regarding the long-term impact of MPs on the soil. Our work underscores the importance of continued research efforts and the adoption of standardised approaches to address plastic pollution and ensure a sustainable future for our planet.

Tracking industry pollution sources and health risks in China.

Agglomeration of firms significantly increases pollution emission intensity and brings unintended consequences to public health. We develop the pollution emission indices using the firm-level pollutant emission data in China to track pollution intensities at the source using the locally weighted regression approach. Our constant-quality pollutant emission indices for three pollutants (wastewater discharge, COD, and SO2) and the pollution emission heatmaps show decreasing trends for the three pollutants from 1998 to 2012. We also show significant spatial clustering and regional variations in pollution emission trends. Industrial pollution mitigations in China's Eastern and Central regions have been neglected for decades since 2021, when driving economic growth took priority. The regime shifts in pollution controls from the 10th (2000-2005) to the 11th (2006-2010) Five-Year Plan period show the effects of tightening pollution emission controls. Failure to cut pollution emissions at source causes health consequences to residents living and working in nearby polluting industries. The latent environmental hazard could be a ticking time bomb, which could not be delinked from the emergence of cancer villages in the regions. Therefore, enforcing strict and uniform pollution controls and setting clear emission limits at sources can eliminate free-rider problems by polluting firms.

THE STRUCTURE OF THE INCIDENCE OF ONCOHEMATOLOGICAL DISEASES IN ECOLOGICALLY DISADVANTAGED REGIONS OF THE DNIPROPETROVSK REGION FOR THE PERIOD 2006-2017. / СТРУКТУРА ЗАХВОРЮВАНОСТІ НА ОНКОГЕМАТОЛОГІЧНІ ХВОРОБИ В ЕКОЛОГІЧНО НЕБЛАГОПОЛУЧНИХ РЕГІОНАХ ДНІПРОПЕТРОВСЬКОЇ ОБЛАСТІ ЗА ПЕРІОД 2006­2017 РОКІВ).

OBJECTIVE: to conduct a comparative analysis of the incidence of malignant oncohematological diseases structure among the population of the 4 most ecologically disadvantaged cities of the Dnipropetrovsk region, taking into account the possible influence of various adverse environmental factors (radiation and chemical pollution of air, water and soil) for the period 2006-2017. MATERIALS AND METHODS: 1948 cases of acute myeloblastic and lymphoblastic leukemia, chronic myeloid and lymphocytic leukemia in residents of 4 cities of the Dnipropetrovsk region were analyzed, taking into account the possible influence of adverse environmental factors (radiation, air pollution, etc.). We used clinical and hematological data per patient and statistic information on these diseasis incidence in the region. RESULTS: An analysis of the oncohematological patients incidence structure, namely: acute lymphoblastic (C91.0) and myeloblastic leukemia (C92.0), chronic lymphocytic (C91.1) and myeloid (C92.1) leukemia, over 12 years in environmentally disadvantaged cities of Dnipropetrovsk region have been conducted. A comparative analysis of the incidence of these diseases among the population of 4 cities of the Dnipropetrovsk region was carried out, taking into account the possible influence of adverse environmental factors (radiation, air pollution, etc.). An excess of the incidence rates of the above-mentioned oncohematological diseases for the period 2006-2017 was revealed in the cities of Dnipro, Kryvyi Rih, Kamianske and Zhovti Vody, where environmental factors significantly affect the increase in morbidity due to pollution mainly by radioactive and chemical substances.

[The ecological determinancy of development of bronchial asthma in adult population (as exemplified by the Republic of the North Ossetia-Alania].

The intensive impact of anthropogenic factors on health causes more than 40% of all human diseases. First of all, it has to do with respiratory organs and comes out as the main determinant of development of chronic respiratory pathology. The article presents an assessment of negative impact of environmental factors on dynamics of increasing of incidence of bronchial asthma morbidity in the Republic of North Ossetia-Alania. The indicators of the general morbidity that increased up to 75.6% and for the first time detected up to 97.5% over six-year period. The results of present study correspond with the results of similar studies implemented in various territories of Russia indicating at mediation of increasing of bronchial asthma morbidity by negative impact of environment risk factors. In the Republic, over a period of many decades, contribution of the metallurgical plant producing zinc, cadmium, sulfuric acid and zinc-aluminum alloys, to atmospheric air pollution made up not less than 40%. Only two out of eight rural municipal districts are relatively environmentally problem-free today. In rural areas, more than 50% of atmospheric air pollutants is related to carbon oxide. Nowadays, along with industrial emissions into atmospheric air and their accumulation, increases importance of motor transport in environmental pollution. The cars account for 50-70% of all harmful emissions. The presence of harmful substances contained in exhaust gases exceeds permissible standards by 2-3 times. According to the data of systematic analysis of urban air quality, most of the year citizens breathe atmospheric air not meeting normative requirements. The actual situation favors development of bronchial asthma. In the Republic, its morbidity has not decreased for many decades. To improve indicators of bronchial asthma morbidity can be achieved by leveling harmful effects of environment through identification of main sources of environmental troubles. The priority is both to decrease industrial emissions that pollute atmosphere and to transit to more ecologically safe modern power supplies of motor transport facilities.

Hotspots of soil pollution: Possible glyphosate and aminomethylphosphonic acid risks on terrestrial ecosystems and human health.

The study presents a literature review of glyphosate (GLY) occurrence and its breakdown product, aminomethylphosphonic acid (AMPA), in soils worldwide, but with a specific focus on South America. In addition, an ecological risk approach based on the ecotoxicological endpoints for key soil biota (e.g., collembolans, and earthworms) assessed the impact of GLY and AMPA on these organisms. A generic probabilistic model for human health risk was also calculated for the different world regions. For what reports the risk for edaphic species and the level of pollution under the worst-case scenario, the South American continent was identified as the region of most concern. Nonetheless, other areas may also be in danger, but no risk could be calculated due to the lack of data. Since tropical countries are the top food exporters worldwide, the results obtained in this study must be carefully examined for their implications on a global scale. Some of the factors behind the high levels of these two chemicals in soils are debated (e.g., permissive protection policies, the extensive use of genetically modified crops), and some possible guidelines are presented that include, for example, further environmental characterisation and management of pesticide residues. The present review integrates data that can be used as a base by policymakers and decision-makers to develop and implement environmental policies.

NYS Nonprofit Hospital Assessment and Response to Environmental Pollution as Community Health Need: Prevalence in Community Benefit Practices.

CONTEXT: Given the impact of environmental pollution on health and health inequity, there may be substantial value in integrating assessment and response to pollution into nonprofit hospital community benefit processes. Such hospital engagement has not yet been studied. OBJECTIVES: We take a preliminary step of inquiry in investigating if nonprofit hospitals in New York State (NYS) assess, identify, or respond to environmental pollution as part of community benefit processes. DESIGN: This study is of retrospective, observational design. Data were abstracted from community health needs reports (2015-2017), associated implementation plans, and related IRS (Internal Revenue Service) filings from a randomly geographically stratified selection of NYS nonprofit hospitals. PARTICIPANTS: The sample includes 53 hospitals from 23 counties. The sampling frame consists of NYS nonspecialty private nonprofit hospitals. MAIN OUTCOME MEASURES: Dichotomous findings for the following: (1) engagement of environmental pollution in the process of assessment of community health needs; (2) environmental pollution concern identified as a priority community health need; (3) strategic planning present to address pollution identified as community health need; and (4) action taken on same. RESULTS: We found that 60.5% (95% confidence interval [CI], 0.46-0.74) of hospitals evidenced some form of assessment of environmental pollution and 18.9% (95% CI, 0.09-0.32) identified pollution as a priority community health need. However, no hospital went on to take independent or collaborative planning or action to address pollution. In additional analysis, we found that social justice in hospital mission was a positive predictor of assessment of environmental pollution. CONCLUSIONS: For NYS hospitals, we found a substantial presence of assessment and identification of pollution as a community health concern. Our finding of the absence of response to environmental pollution represents a gap in community benefit implementation. This indicates a yet untaken opportunity to address racial and economic environmental health injustices and to improve population health.

Sustainability of Italian seaports located near contaminated sites: results of an exploratory analysis.

INTRODUCTION: Ports are strategic areas of economic importance, but they are also very critical contexts. Many Italian ports are included in contaminated sites of concern for remediation, with the presence of pressure factors that overload the burden capacity of local ecosystems and communities. AIM: The aim of this study is to characterize Italian seaport areas through a general theoretical path on the theme of ports-sustainability-local communities, identifying the ports located in municipalities included in contaminated sites studied by the SENTIERI Project (Epidemiological Study of Residents in Italian Contaminated Sites). Many of the selected ports, are being part of complex industrial areas, where, in addition to the port area, there are other sources of environmental contamination potentially harmful to health. RESULTS: Excesses risk were observed for mesothelioma and for respiratory diseases, pathologies for which there is epidemiological evidence of an excess of risk associated with residence in port areas. DISCUSSION: The strong environmental pressures that characterize these areas make it necessary to adopt adequate environmental and health protection measures.

Organic composts as A vehicle for the entry of microplastics into the environment: A comprehensive review.

Plastic pollution is a widespread issue that poses a threat to agroecosystems. Recent data on microplastic (MP) pollution from compost and its application to soil have highlighted the potential impact of micropollutants that may be transferred from compost. Thus, we aim with this review to elucidate the distribution-occurrence, characterization, fate/transport, and potential risk of MPs from organic compost to gain comprehensive knowledge and mitigate the adverse impacts of compost application. The concentration of MPs in compost was up to thousands of items/kg. Among micropollutants, fibers, fragments, and films are the most common, with small MPs having a higher potential to absorb other pollutants and cause harm to organisms. Various synthetic polymers, including polyethylene (PE), polypropylene (PP), polyethylene terephthalate (PET), polystyrene (PS), polyvinyl chloride (PVC), polyester (PES), and acrylic polymers (AP), have been widely used of plastic items. MPs are emerging pollutants that can have diverse effects on soil ecosystems, as they can transfer potential pollutants from MPs to compost and then to the soil. Following the microbial degradation scheme, the transfer chain from plastics to compost to soil can be broken down into main stages, i.e., colonization - (bio)fragmentation - assimilation - and mineralization. Microorganisms and adding biochar play an essential role during composting, which can be an effective solution to enhance MP degradation. Findings have shown that stimulating free radical generation could promote the biodegradation efficacy of MPs and possibly remove their occurrence in compost, thereby reducing their contribution to ecosystem pollution. Furthermore, future recommendations were discussed to reduce ecosystem risks and health challenges.

Impacto medioambientalde los servicios de Urgenciasen la Salud Pública: una herramienta de valoración / Carbon footprinting the Emergency Departments in the United Kingdom: an assessment too

FUNDAMENTOS: El cambio climático está directamente relacionado con el aumento de ciertas patologías como enfermedadescardiovasculares, respiratorias y/o infecciosas, así como con la desnutrición, provocada por la reducción de los alimentos disponibles,y el deterioro de la salud mental. La evidencia ha señalado que los servicios sanitarios son responsables del 4%-5% de las emisionesde gases efecto invernadero en todo el mundo. El objetivo de este estudio fue diseñar una herramienta de evaluación de la huella decarbono de los servicios de Urgencias.MÉTODOS: Se diseñó la herramienta a través de cinco etapas. En primer lugar, se seleccionaron las categorías a incluir en laherramienta desde una revisión de la literatura. Posteriormente, se determinaron el alcance y límites, se seleccionaron los factoresde conversión, se recopilaron datos del servicio de Urgencias del Royal Free Hospital de Londres como sitio piloto y se seleccionó elmétodo de cálculo de la huella de carbono.RESULTADOS: La herramienta resultante se dividió en tres ámbitos, y cada ámbito en una o más categorías que contienen varioselementos. Los datos se recopilaron de diferentes fuentes, como facturación, medidores, auditorías y encuestas. La herramienta sepresentó en un documento de Microsoft Excel.CONCLUSIONES: Esta herramienta de evaluación de carbono ofrece una oportunidad para monitorear las emisiones de carbonoen los servicios de Urgencias. Pretende proporcionar una valoración de la huella de carbono de referencia, identificando puntoscríticos de emisión dentro del servicio, que puede dar lugar a iniciativas ambientales locales.PALABRAS CLAVE: Huella de carbono; Emisiones de gases efecto invernadero; Servicios de Urgencias; Evaluación del ciclo devida; Impacto medioambiental.(AU)

BACKGROUND: Climate change is directly related to increasing medical conditions such as cardiovascular, respiratory and/or infectious diseases, as well as malnutrition and mental illness caused by the reduction of available food and the growth of situations with significant emotional impact, respectively. Evidence showed that healthcare services are responsible for 4-5% of the greenhouse gas emissions worldwide. The aim of this study is the development of an assessment tool to evaluate the carbon footprint ofemergency departments.METHODS: The development of the proposed assessment tool followed five stages. Firstly, the categories of GHGs to be included in the assessment tool were determined through a literature review. This was followed by establishment of scopes and boundaries, selection of conversion factors, collection of data from the Emergency Department at the Royal Free Hospital in London as a pilot site, and finally, the development of methodology to assess the carbon footprint.RESULTS : The assessment tool was divided in three scopes and each scope included one or more categories containing several items. Data was collected from different sources such as meters invoicing and billing, auditing, and surveys. The tool is presented in a Microsoft Excel document.CONCLUSIONS : This carbon assessment tool offers an opportunity to monitor carbon emissions in emergency departments, aiming to proliferate environmental strategies. The assessment tool seeks to provide a baseline carbon footprint assessment, identifying carbon hotspots within the department. The identification of these areas of intensive carbon emissions can help guide and focuslocal environmental initiatives that later can be monitored with a follow-up assessment to evaluate their effectiveness.KEYWORDS: Carbon footprint; Greenhouse gases emissions; Emergency departments; Life cycle assessment; Environmental impact.(AU)

Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution.

Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease and represents an increasing public health issue given the limited treatment options and its association with several other metabolic and inflammatory disorders. The epidemic, still growing prevalence of NAFLD worldwide cannot be merely explained by changes in diet and lifestyle that occurred in the last few decades, nor from their association with genetic and epigenetic risk factors. It is conceivable that environmental pollutants, which act as endocrine and metabolic disruptors, may contribute to the spreading of this pathology due to their ability to enter the food chain and be ingested through contaminated food and water. Given the strict interplay between nutrients and the regulation of hepatic metabolism and reproductive functions in females, pollutant-induced metabolic dysfunctions may be of particular relevance for the female liver, dampening sex differences in NAFLD prevalence. Dietary intake of environmental pollutants can be particularly detrimental during gestation, when endocrine-disrupting chemicals may interfere with the programming of liver metabolism, accounting for the developmental origin of NAFLD in offspring. This review summarizes cause-effect evidence between environmental pollutants and increased incidence of NAFLD and emphasizes the need for further studies in this field.

Environmental Pollution and the Risk of Developing Metabolic Disorders: Obesity and Diabetes.

To meet the increased need for food and energy because of the economic shift brought about by the Industrial Revolution in the 19th century, there has been an increase in persistent organic pollutants (POPs), atmospheric emissions and metals in the environment. Several studies have reported a relationship between these pollutants and obesity, and diabetes (type 1, type 2 and gestational). All of the major pollutants are considered to be endocrine disruptors because of their interactions with various transcription factors, receptors and tissues that result in alterations of metabolic function. POPs impact adipogenesis, thereby increasing the prevalence of obesity in exposed individuals. Metals impact glucose regulation by disrupting pancreatic ß-cells, causing hyperglycemia and impaired insulin signaling. Additionally, a positive association has been observed between the concentration of endocrine disrupting chemicals (EDCs) in the 12 weeks prior to conception and fasting glucose levels. Here, we evaluate what is currently known regarding the link between environmental pollutants and metabolic disorders. In addition, we indicate where further research is required to improve our understanding of the specific effects of pollutants on these metabolic disorders which would enable implementation of changes to enable their prevention.